Why are Labradors always hungry? A 2016 study at the University of Cambridge found that Labradors’ insatiable appetite might be due to changes in a specific gene, called the POMC gene. When the POMC gene is changed, the chemical messages which tell a Lab when he’s full don’t work properly. About a quarter of Labradors have this genetic change, but there are other reasons why other Labs might have an insatiable appetite too!